منابع مشابه
Gap junction structures after experimental alteration of junctional channel conductance
Gap junctions are known to present a variety of different morphologies in electron micrographs and x-ray diffraction patterns. This variation in structure is not only seen between gap junctions in different tissues and organisms, but also within a given tissue. In an attempt to understand the physiological meaning of some aspects of this variability, gap junction structure was studied following...
متن کاملGap junction structures: Analysis of the x-ray diffraction data
Models for the spatial distribution of protein, lipid and water in gap junction structures have been constructed from the results of the analysis of X-ray diffraction data described here and the electron microscope and chemical data presented in the preceding paper (Caspar, D. L. D., D. A. Goodenough, L. Makowski, and W.C. Phillips. 1977. 74:605-628). The continuous intensity distribution on th...
متن کاملOn gap junction structure
We have studied the stain distribution within rat liver gap junctions for specimens prepared by thin sectioning and negative staining. Pools of stain molecules exist in two specific locations with respect to the distinctive morphological units (connexons) of the junction. One pool of stain surrounds the connexons and is restricted to the extracellular space in the gap between the adjacent plasm...
متن کاملNonredundant gap junction functions.
The need for molecular heterogeneity of gap junction channel proteins in vivo has been enigmatic. Recently, functional replacement of one channel gene with another in mice and flies has revealed that cellular health depends not simply on gap junction communication but also requires the correct type of intercellular channel subunit.
متن کاملGap Junction Voltage Dependence
All vertebrate gap junction channels display voltage-dependent gating. Historically, voltage-dependent behaviors have been characterized as being transjunctional voltage (Vj) and membrane voltage (Vm) dependent. The transjunctional voltage dependence of gap junction channels composed of two identical hemichan-nels, each composed of identical connexins subunits (a homotypic channel) is usually s...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 1982
ISSN: 0006-3495
DOI: 10.1016/s0006-3495(82)84663-8